Essential role of microglia in the fast antidepressant action of ketamine and hypidone hydrochloride (YL-0919)

• Main Authors: Hai-Xia Chang (Author), Wei Dai (Author), Jin-Hao Bao (Author), Jin-Feng Li (Author), Ji-Guo Zhang (Author), Yun-Feng Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Intracerebral microglia play a vital role in mediating central immune response, neuronal repair and synaptic pruning, but its precise role and mechanism in fast action of antidepressants have remained unknown. In this study, we identified that the microglia contributed to the rapid act...