Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq

• Główni autorzy: Vahid Akbari (Autor), Vincent C.T. Hanlon (Autor), Kieran O'Neill (Autor), Louis Lefebvre (Autor), Kasmintan A. Schrader (Autor), Peter M. Lansdorp (Autor), Steven J.M. Jones (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Summary: Hundreds of loci in human genomes have alleles that are methylated differentially according to their parent of origin. These imprinted loci generally show little variation across tissues, individuals, and populations. We show that such loci can be used to distinguish the maternal and patern...