BAP1 Downregulates NRF2 Target Genes and Exerts Anti-Tumorigenic Effects by Deubiquitinating KEAP1 in Lung Adenocarcinoma

• Main Authors: Jong-Su Kang (Author), Le Ba Nam (Author), Ok-Kyung Yoo (Author), Kyeong Lee (Author), Young-Ah Suh (Author), Dalyong Kim (Author), Woo Kyung Kim (Author), Chi-Yeon Lim (Author), Haeseung Lee (Author), Young-Sam Keum (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

KELCH-ECH-associated protein 1 (KEAP1) is an adaptor protein of Cullin 3 (CUL3) E3 ubiquitin ligase that targets a redox sensitive transcription factor, NF-E2-related factor 2 (NRF2). BRCA1-associated protein 1 (BAP1) is a tumor suppressor and deubiquitinase whose mutations increase the risk of seve...