Cost-Effectiveness of UGT1A1*28 Genotyping in Preventing Severe Neutropenia Following FOLFIRI Therapy in Colorectal Cancer.

• Main Authors: Solen Pichereau (Author), Anne Le Louarn (Author), Thierry Lecomte (Author), Hélène Blasco (Author), Chantal Le Guellec (Author), Hélène Bourgoin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Functional polymorphisms of the UGT1A1 gene, particularly the UGT1A1*28 variant, are associated with the severity of the bone marrow suppression in patients with metastatic colorectal cancer receiving irinotecan. This study assesses the cost-effectiveness of screening for UGT1A1*28 polymorp...