Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization

• Main Authors: Pier Giorgio Cojutti (Author), Milo Gatti (Author), Matteo Rinaldi (Author), Tommaso Tonetti (Author), Cristiana Laici (Author), Chiara Mega (Author), Antonio Siniscalchi (Author), Maddalena Giannella (Author), Pierluigi Viale (Author), Federico Pea (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: optimal treatment of Gram-negative infections in critically ill patients is challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility and limited therapeutic options. The aim of this study was to assess the impact of maximizing Css/MIC ratio on efficacy...