Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation

• 主要な著者: Rui-juan Xu (著者), Tao Ling (著者), Hong Tang (著者), Wei-hong Ge (著者), Qing Jiang (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Rivaroxaban is commonly used for the prophylaxis of venous thromboembolism (VTE) for patients undergoing major orthopedic surgery. Rivaroxaban is primarily eliminated by hepatic CYP450 metabolism and renal excretion. Rifampin is a commonly used antibiotic for prosthetic joint infections (PJI) and a...