Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells
Abstract.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations of p38, JNK, and ERK. The Cd-induced VC...
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| Format: | Book |
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Elsevier,
2009-01-01T00:00:00Z.
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| 001 | doaj_947ffb93e4dc45d48eee79a14b534624 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Sung Lyea Park |e author |
| 700 | 1 | 0 | |a You-Mie Kim |e author |
| 700 | 1 | 0 | |a Jin-Hee Ahn |e author |
| 700 | 1 | 0 | |a Soo Hwan Lee |e author |
| 700 | 1 | 0 | |a Eun Joo Baik |e author |
| 700 | 1 | 0 | |a Chang-Hyun Moon |e author |
| 700 | 1 | 0 | |a Yi-Sook Jung |e author |
| 245 | 0 | 0 | |a Cadmium Stimulates the Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) via p38 Mitogen-Activated Protein Kinase (MAPK) and JNK Activation in Cerebrovascular Endothelial Cells |
| 260 | |b Elsevier, |c 2009-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.09001SC | ||
| 520 | |a Abstract.: In this study, we examined the effect of Cd on the expression of vascular cell adhesion molecule-1 (VCAM-1) and its mechanisms in bEnd.3 cells. The treatment with Cd increased protein and mRNA expressions of VCAM-1 and increased the phosphorylations of p38, JNK, and ERK. The Cd-induced VCAM-1 expression was significantly suppressed by either a specific p38 mitogen-activated protein kinase (MAPK) inhibitor (SB202190) or a JNK inhibitor (SP600125), but not by an ERK inhibitor (U0126). These results suggest that Cd induces the expression of VCAM-1, at least in part, via p38 and JNK pathways in bEnd.3 cells. Keywords:: cadmium, vascular cell adhesion molecule-1 (VCAM-1), mitogen-activated protein kinase (MAPK) | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 110, Iss 3, Pp 405-409 (2009) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319311612 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/947ffb93e4dc45d48eee79a14b534624 |z Connect to this object online. |