Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

• Main Authors: Xi Xu (Author), Jie Ren (Author), Yinghe Ma (Author), Hongting Liu (Author), Quanjin Rong (Author), Yifan Feng (Author), Yameng Wang (Author), Yu Cheng (Author), Ruijia Ge (Author), Zhiyu Li (Author), Jinlei Bian (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the aim of discovering novel IDO1 inhibitors, a combined similarity search and molecular docking approach was employed to the discovery of 32 hit compounds. Testing the screened hit compounds has led to several novel submicromolar inhibitors. Especially for compounds LVS-019 with cyanopyridine...