Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

• Main Authors: Minglu Zhou (Author), Lijia Li (Author), Lian Li (Author), Xi Lin (Author), Fengling Wang (Author), Qiuyi Li (Author), Yuan Huang (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (HPMA) polymer-drug conjugates, we designed an...