Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation.

• Main Authors: Nathanne Santos Ferreira (Author), Stêfany Bruno Assis Cau (Author), Marcondes Alves Barbosa Silva (Author), Carla Pavan Manzato (Author), Fabíola Leslie Antunes Cardoso Mestriner (Author), Takayuki eMatsumoto (Author), Fernando Silva Carneiro (Author), Rita Cassia Tostes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aldosterone promotes non-genomic effects in endothelial and vascular smooth muscle cells via activation of mineralocorticoid receptors (MR) and G protein-coupled estrogen receptors (GPER). GPER activation is associated with beneficial/protective effects in the vasculature. Considering that vascular...