Confounding factors in profiling of locus-specific human endogenous retrovirus (HERV) transcript signatures in primary T cells using multi-study-derived datasets

• Hauptverfasser: Martin V. Hamann (Verfasst von), Maisha Adiba (Verfasst von), Ulrike C. Lange (Verfasst von)
• Format: Buch
• Veröffentlicht: BMC, 2023-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Human endogenous retroviruses (HERV) are repetitive sequence elements and a substantial part of the human genome. Their role in development has been well documented and there is now mounting evidence that dysregulated HERV expression also contributes to various human diseases. Wh...