Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies
The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphoid cell development. The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of-function alterations in the pathway contribute to malignant transformation of lymphocytes. Binding of IL-7 to the IL-7 re...
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MDPI AG,
2021-05-01T00:00:00Z.
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