SNS-032 attenuates liver fibrosis by anti-active hepatic stellate cells via inhibition of cyclin dependent kinase 9

• Main Authors: Xiao-Li He (Author), Yong-Hong Hu (Author), Jia-Mei Chen (Author), Ding-Qi Zhang (Author), Hai-Lin Yang (Author), Lin-Zhang Zhang (Author), Yong-Ping Mu (Author), Hua Zhang (Author), Gao-Feng Chen (Author), Wei Liu (Author), Ping Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver fibrosis is a common pathological process of all chronic liver diseases. Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis. Cyclin-dependent kinase 9 (CDK9) is a cell cycle kinase that regulates mRNA transcription and elongation. A CDK9 inhibitor SNS-032 ha...