TNF-α and IL-1β Do Not Induce Langerhans Cell Migration by Inhibiting TGFβ Activation

• Main Authors: Jacinto S. De La Cruz Diaz (Author), Toshiro Hirai (Author), Breanna Anh-Thu Nguyen (Author), Yukari Zenke (Author), Yi Yang (Author), Haiyue Li (Author), Stephen Nishimura (Author), Daniel H. Kaplan (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the skin, Langerhans cells (LCs) require autocrine latent TGFβ that is transactivated by the integrins ανβ6 and ανβ8 expressed by keratinocytes (KCs) for long-term epidermal retention. Selective expression of a ligand-independent, constitutively active form of TGFβR1 inhibits LC migration during...