Formulation and characterization of α-mangostin in chitosan nanoparticles coated by sodium alginate, sodium silicate, and polyethylene glycol

• Main Authors: Nasrul Wathoni (Author), Agus Rusdin (Author), Erma Febriani (Author), Destiana Purnama (Author), Wahnidar Daulay (Author), Sundoro Y Azhary (Author), Camellia Panatarani (Author), I Made Joni (Author), Ronny Lesmana (Author), Keiichi Motoyama (Author), Muchtaridi Muchtaridi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: α-mangostin, one of the xanthone derivative compounds isolated from Garcinia mangostana L. peel extract, has an excellent anticancer efficacy. However, α-mangostin has a lack of site specificity, poor cells selectivity, and low aqueous solubility. Polymeric nanoparticles formulation can be...