Pathophysiological and behavioral deficits in developing mice following rotational acceleration-deceleration traumatic brain injury

• Main Authors: Guoxiang Wang (Author), Yi Ping Zhang (Author), Zhongwen Gao (Author), Lisa B. E. Shields (Author), Fang Li (Author), Tianci Chu (Author), Huayi Lv (Author), Thomas Moriarty (Author), Xiao-Ming Xu (Author), Xiaoyu Yang (Author), Christopher B. Shields (Author), Jun Cai (Author)
• Format: Book
• Published: The Company of Biologists, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abusive head trauma (AHT) is the leading cause of death from trauma in infants and young children. An AHT animal model was developed on 12-day-old mice subjected to 90° head extension-flexion sagittal shaking repeated 30, 60, 80 and 100 times. The mortality and time until return of consciousness wer...