Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects

• Main Authors: SeungRee Seo (Author), Gwan-Young Kim (Author), Min-Hwan Kim (Author), Kyung Won Lee (Author), Min-Jae Kim (Author), Mansingh Chaudhary (Author), Khadka Bikram (Author), Taeheon Kim (Author), Seungmok Choi (Author), Heejin Yang (Author), Joo Won Park (Author), Dae-Duk Kim (Author), Ki-Taek Kim (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the various therapeutic benefits and high tolerance of orally administered silybin, poor water-solubility can be the main restrictive physicochemical feature, which results in low oral bioavailability in the absorption. A milk thistle nanocrystal formulation (HM40) was prepared using a modif...