Three-component Castagnoli-Cushman reaction with ammonium acetate delivers 2-unsubstituted isoquinol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase (PARP)

• প্রধান লেখক: Alexander Safrygin (লেখক), Petr Zhmurov (লেখক), Dmitry Dar'in (লেখক), Sergey Silonov (লেখক), Mariia Kasatkina (লেখক), Yulia Zonis (লেখক), Maxim Gureev (লেখক), Mikhail Krasavin (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

An earlier described three-component variant of the Castagnoli-Cushman reaction employing homophthalic anhydrides, carbonyl compound and ammonium acetate was applied towards the preparation of 1-oxo-3,4-dihydroisoquinoline-4-carboxamides with variable substituent in position 3. These compounds displ...