First studies on tumor associated carbonic anhydrases IX and XII monoclonal antibodies conjugated to small molecule inhibitors

• Κύριοι συγγραφείς: Chiara Testa (Συγγραφέας), Anna Maria Papini (Συγγραφέας), Reinhard Zeidler (Συγγραφέας), Daniela Vullo (Συγγραφέας), Fabrizio Carta (Συγγραφέας), Claudiu T. Supuran (Συγγραφέας), Paolo Rovero (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

We report for the first time Antibody-Drug-Conjugates (ADCs) containing human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) directed Monoclonal Antibodies (MAbs) linked to low molecular weight inhibitors of the same enzymes by means of hydrophilic peptide spacers. In agreement with the incorporated CA dir...