FMR1 Low Zone CGG Repeats: Phenotypic Associations in the Context of Parenting Stress

• Main Authors: Marsha R. Mailick (Author), Jinkuk Hong (Author), Leann Smith DaWalt (Author), Jan S. Greenberg (Author), Arezoo Movaghar (Author), Mei Wang Baker (Author), Paul J. Rathouz (Author), Murray H. Brilliant (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The FMR1 gene on the X chromosome has varying numbers of CGG repeats. The modal number is 30, and expansion to >200 results in fragile X syndrome, but the copy number extends down to 6. Past research suggests that individuals whose CGGs are in the "low zone" (LZ; defined here as ≤ 25 CG...