Linearolactone Induces Necrotic-like Death in <i>Giardia intestinalis</i> Trophozoites: Prediction of a Likely Target

• Main Authors: Raúl Argüello-García (Author), Fernando Calzada (Author), Bibiana Chávez-Munguía (Author), Audifás-Salvador (Author), Elihú Bautista (Author), Elizabeth Barbosa (Author), Claudia Velazquez (Author), Marta Elena Hernández-Caballero (Author), Rosa Maria Ordoñez-Razo (Author), José Antonio Velázquez-Domínguez (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Linearolactone (LL) is a <i>neo</i>-clerodane type diterpene that has been shown to exert giardicidal effects; however, its mechanism of action is unknown. This work analyzes the cytotoxic effect of LL on <i>Giardia intestinalis</i> trophozoites and identifies proteins that c...