Orientia tsutsugamushi in human scrub typhus eschars shows tropism for dendritic cells and monocytes rather than endothelium.

• Main Authors: Daniel H Paris (Author), Rattanaphone Phetsouvanh (Author), Ampai Tanganuchitcharnchai (Author), Margaret Jones (Author), Kemajittra Jenjaroen (Author), Manivanh Vongsouvath (Author), David P J Ferguson (Author), Stuart D Blacksell (Author), Paul N Newton (Author), Nicholas P J Day (Author), Gareth D H Turner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scrub typhus is a common and underdiagnosed cause of febrile illness in Southeast Asia, caused by infection with Orientia tsutsugamushi. Inoculation of the organism at a cutaneous mite bite site commonly results in formation of a localized pathological skin reaction termed an eschar. The site of dev...