Development and Evaluation of Raloxifene-Hydrochloride-Loaded Supersaturatable SMEDDS Containing an Acidifier

• Main Authors: Jong-Hwa Lee (Author), Hak Hyung Kim (Author), Young Ho Cho (Author), Tae-Sung Koo (Author), Gye Won Lee (Author)
• Format: Book
• Published: MDPI AG, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Raloxifene hydrochloride (RLH) was formulated into a pH-modified supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) to increase drug solubility and dissolution rate. Optimal formulations of pH-modified S-SMEDDSs were developed by incorporating hydroxypropyl-cellulose-L as a preci...