Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules

• المؤلفون الرئيسيون: Hubert Gorny (مؤلف), Angélique Mularoni (مؤلف), Jean-Guy Delcros (مؤلف), Céline Freton (مؤلف), Jordane Preto (مؤلف), Isabelle Krimm (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear. Small-molecule ligands specifically interacting with the channel...