Impact of Albumin and Omeprazole on Steady-State Population Pharmacokinetics of Voriconazole and Development of a Voriconazole Dosing Optimization Model in Thai Patients with Hematologic Diseases

• Main Authors: Buddharat Khan-asa (Author), Baralee Punyawudho (Author), Noppaket Singkham (Author), Piyawat Chaivichacharn (Author), Ekapun Karoopongse (Author), Preecha Montakantikul (Author), Methee Chayakulkeeree (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to identify factors that significantly influence the pharmacokinetics of voriconazole in Thai adults with hematologic diseases, and to determine optimal voriconazole dosing regimens. Blood samples were collected at steady state in 65 patients (237 concentrations) who were taking vor...