Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine

• প্রধান লেখক: Youssef Sari (লেখক), Ghadeer M.S. Swiss (লেখক), Fatin A. Alrashedi (লেখক), Kholoud A. Baeshen (লেখক), Sultan A. Alshammari (লেখক), Shakir D. Alsharari (লেখক), Nemat Ali (লেখক), Abdullah F. Alasmari (লেখক), Ali Alhoshani (লেখক), Alaa A. Alameen (লেখক), Wayne E. Childers (লেখক), Magid Abou-Gharbia (লেখক), Fawaz Alasmari (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2024-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1 (GLT-1), which regulates the majority of glutamate uptake. Studies from our lab revealed that beta-lactam antibiotic, ceftriaxone, attenuated hydrocodone-induced downregulation of GLT-1 as well as cystine/gl...