Effects of novel beta-lactam, MC-100093, and ceftriaxone on astrocytic glutamate transporters and neuroinflammatory factors in nucleus accumbens of C57BL/6 mice exposed to escalated doses of morphine

• Main Authors: Youssef Sari (Author), Ghadeer M.S. Swiss (Author), Fatin A. Alrashedi (Author), Kholoud A. Baeshen (Author), Sultan A. Alshammari (Author), Shakir D. Alsharari (Author), Nemat Ali (Author), Abdullah F. Alasmari (Author), Ali Alhoshani (Author), Alaa A. Alameen (Author), Wayne E. Childers (Author), Magid Abou-Gharbia (Author), Fawaz Alasmari (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1 (GLT-1), which regulates the majority of glutamate uptake. Studies from our lab revealed that beta-lactam antibiotic, ceftriaxone, attenuated hydrocodone-induced downregulation of GLT-1 as well as cystine/gl...