Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation

• Main Authors: Ruey-Chyi Su (Author), Andrew Plesniarski (Author), Zhujun Ao (Author), Joshua Kimani (Author), Aida Sivro (Author), Walter Jaoko (Author), Frank A Plummer (Author), Xiaojian Yao (Author), Terry Blake Ball (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40-60% reduction in endogenous IRF-1 (interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early HIV replication. This study examined the functional consequences of reducing e...