Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model

• Main Authors: Roza Azadi (Author), Seyyedeh Elaheh Mousavi (Author), Negar Motakef Kazemi (Author), Hasan Yousefi-Manesh (Author), Seyed Mahdi Rezayat (Author), Mahmoud Reza Jaafari (Author)
• Format: Book
• Published: BMC, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on the secretion of inflammatory cytokin...