The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis

• Main Authors: Md. Zahirul Haque Bhuyan (Author), Yukihiko Tamura (Author), Eri Sone (Author), Yuki Yoshinari (Author), Chizuko Maeda (Author), Mariko Takahashi (Author), Yasuhiko Tabata (Author), Ramachandran Murali (Author), Yoshihiro Waki (Author), Kazuhiro Aoki (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently found that the receptor activator of NF-κB ligand (RANKL)-binding peptide, OP3-4 stimulated the differentiation of both chondrocytes and osteoblasts. OP3-4 is also shown to inhibit cartilage degeneration. To clarify whether the peptide can inhibit cartilage degeneration without stimulati...