The journey of canakinumab; on- and off-label indications

• Main Authors: Daniela Marotto (Author), Alberto Batticciotto (Author), Angela Ceribelli (Author), Piercarlo Sarzi Puttini (Author)
• Formato: Livro
• Publicado em: Verduci Editore, 2019-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The role of interleukin-1 (IL-1) has been studied in many diseases, ranging from auto-inflammatory diseases to malignancies, and much has been discovered. There are currently four IL-1 inhibitors available, but only two have been approved in Europe: the receptor antagonist anakinra, and the IL-1b se...