Convergence of dopamine and glutamate signalling onto striatal ERK activation in response to drugs of abuse.

• Main Authors: Emma eCahill (Author), Marine eSalery (Author), Peter eVanhoutte (Author), Jocelyne eCaboche (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite their distinct targets, all addictive drugs commonly abused by humans evoke increases in dopamine (DA) concentration within the striatum. The main DA G-Protein Coupled Receptors (GPCRs) expressed by medium-sized spiny neurons (MSNs) of the striatum are the D1R and D2R, which are positively a...