Direct interaction of DNMT inhibitors to PrPC suppresses pathogenic process of prion

• Asıl Yazarlar: Dae-Hwan Kim (Yazar), Chunyan Ren (Yazar), Chongsuk Ryou (Yazar), Jiaojie Li (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2019-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The conversion of the normal cellular prion protein (PrPC) to the misfolded pathogenic scrapie prion protein (PrPSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-p...