Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience

• Автори: Jianbang Chiang (Автор), Jeanette Yuen (Автор), Tarryn Shaw (Автор), Hui Xuan Goh (Автор), Shao-Tzu Li (Автор), Eliza Courtney (Автор), Joanne Ngeow (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes. Predictive testing is the optimal approach to identify asymptomatic at-risk relatives to guide gene-directed surveillance for early cancer detection and...