Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience

• Main Authors: Jianbang Chiang (Author), Jeanette Yuen (Author), Tarryn Shaw (Author), Hui Xuan Goh (Author), Shao-Tzu Li (Author), Eliza Courtney (Author), Joanne Ngeow (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes. Predictive testing is the optimal approach to identify asymptomatic at-risk relatives to guide gene-directed surveillance for early cancer detection and...