Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

• Main Authors: Mariana Eksteen (Author), Gøril Heide (Author), Heidi Tiller (Author), Yan Zhou (Author), Nora Hersoug Nedberg (Author), Inigo Martinez-Zubiaurre (Author), Anne Husebekk (Author), Bjørn R. Skogen (Author), Tor B. Stuge (Author), Mette Kjær (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that...