Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

• Egile Nagusiak: Peter L. Lee (Egilea), Yuefeng Tang (Egilea), Huawei Li (Egilea), David A. Guertin (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2016-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Normal adipose tissue growth and function is critical to maintaining metabolic homeostasis and its excess (e.g. obesity) or absence (e.g. lipodystrophy) is associated with severe metabolic disease. The goal of this study was to understand the mechanisms maintaining healthy adipose tissue...