Molecular Pathogenesis of Desmoid Tumors
Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which beta-catenin/TCF3 mediated Wnt signaling is activated. More than 80% of desmoid tumors contain activating mutations in ß-Catenin which leads to up-regulation of ß-Catenin. The functional consequences of up-regu...
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Tehran University of Medical Sciences,
2005-03-01T00:00:00Z.
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