A Nanoparticle Delivery of Plasmid Encoding Hepatocyte Growth Factor for Gene Therapy of Silicosis in Mice

• Main Authors: Haiying Duan (Author), Peng Gao (Author), Xiaochen Cheng (Author), Yuxin Lu (Author), Chunsheng Hu (Author), Xuefeng Zhu (Author), Xiaoying Wang (Author), Dujuan Li (Author), Fengjun Xiao (Author), Li Du (Author), Yunmei Liu (Author), Qinglin Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Silicosis is a serious occupational disease that is characterized by pulmonary infiltrates and fibrosis and is often refractory to current treatments. New therapeutic strategies for silicosis are needed. Hepatocyte growth factor (HGF) is a latent anti-inflammatory and anti-fibrotic growth f...