MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

• المؤلفون الرئيسيون: William E. Tidyman (مؤلف), Alice F. Goodwin (مؤلف), Yoshiko Maeda (مؤلف), Ophir D. Klein (مؤلف), Katherine A. Rauen (مؤلف)
• التنسيق: كتاب
• منشور في: The Company of Biologists, 2022-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Costello syndrome (CS) is a congenital disorder caused by heterozygous activating germline HRAS mutations in the canonical Ras/mitogen-activated protein kinase (Ras/MAPK) pathway. CS is one of the RASopathies, a large group of syndromes caused by mutations within various components of the Ras/MAPK p...