Physical Activity and Inhibition of ACE Additively Modulate ACE/ACE-2 Balance in Heart Failure in Mice

• Main Authors: Urszula Tyrankiewicz (Author), Mariola Olkowicz (Author), Piotr Berkowicz (Author), Magdalena Jablonska (Author), Ryszard T. Smolenski (Author), Jerzy A. Zoladz (Author), Stefan Chlopicki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiotensin-converting enzyme inhibition (ACE-I) and physical activity favorably modulate the ACE/ACE-2 balance. However, it is not clear whether physical activity and ACE-I could synergistically modulate ACE/ACE-2 balance in the course of heart failure (HF). Here, we studied the effects of combined...