Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model

• Main Authors: Jian-Hua Chen (Author), Kim Jee Goh (Author), Nuno Rocha (Author), Matthijs P. Groeneveld (Author), Marina Minic (Author), Timothy G. Barrett (Author), David Savage (Author), Robert K. Semple (Author)
• Format: Book
• Published: The Company of Biologists, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adipose tissue is the primary tissue affected in most single gene forms of severe insulin resistance, and growing evidence has implicated it as a site at which many risk alleles for insulin resistance identified in population-wide studies might exert their effect. There is thus increasing need for h...