Exendin-4 Potentiates Insulinotropic Action Partly via Increasing β-Cell Proliferation and Neogenesis and Decreasing Apoptosis in Association With the Attenuation of Endoplasmic Reticulum Stress in Islets of Diabetic Rats

• Main Authors: Dae Young Kwon (Author), Young Sup Kim (Author), Il Sung Ahn (Author), Da Sol Kim (Author), Suna Kang (Author), Snag Mee Hong (Author), Sunmin Park (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exendin-4, a long-acting glucagon-like peptide-1-receptor agonist, is known to enhance β-cell function, but the active mechanism by which it modulates β-cell mass still remains unclear. We investigated what the long-term effects of exendin-4 (300 pmol/kg body weight per day) on β-cell function and m...