Adenine-Induced Chronic Renal Failure in Rats: A Model of Chronic Renocardiac Syndrome with Left Ventricular Diastolic Dysfunction but Preserved Ejection Fraction

• Main Authors: Pavlos Kashioulis (Author), Jaana Lundgren (Author), Emman Shubbar (Author), Lisa Nguy (Author), Aso Saeed (Author), Cecilia Wallentin Guron (Author), Gregor Guron (Author)
• Format: Book
• Published: Karger Publishers, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Cardiovascular disease is the major cause of death in patients with chronic kidney disease (CKD). Rats with adenine-induced chronic renal failure (ACRF) develop severe renal insufficiency and metabolic abnormalities that closely resemble those in patients with uremia. The aim of the...