Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation

Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation

Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this presumed benefit, considerably more non-selective HDAC inhibitors have undergone clinical trials. In this report, we d...

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Main Authors: Dusan Ruzic (Author), Bernhard Ellinger (Author), Nemanja Djokovic (Author), Juan F. Santibanez (Author), Sheraz Gul (Author), Milan Beljkas (Author), Ana Djuric (Author), Arasu Ganesan (Author), Aleksandar Pavic (Author), Tatjana Srdic-Rajic (Author), Milos Petkovic (Author), Katarina Nikolic (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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