Magnetic resonance imaging and ultrasound elastography in the context of preclinical pharmacological research: significance for the 3R principles

• Main Authors: Michael Obrecht (Author), Stefan Zurbruegg (Author), Nathalie Accart (Author), Christian Lambert (Author), Arno Doelemeyer (Author), Birgit Ledermann (Author), Nicolau Beckmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 3Rs principles-reduction, refinement, replacement-are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing their number as well as searching for means to replace th...