Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study

• Main Authors: Florian Uhle (Author), Christoph Lichtenstern (Author), Thorsten Brenner (Author), Thomas Fleming (Author), Christian Koch (Author), Andreas Hecker (Author), Christian Heiss (Author), Peter Paul Nawroth (Author), Stefan Hofer (Author), Markus Alexander Weigand (Author), Katja Weismüller (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In...