YTHDC1 inhibits autophagy-dependent NF-κB signaling by stabilizing Beclin1 mRNA in macrophages

• Ngā kaituhi matua: Li Zhou (Author), Ling Zhang (Author), Yan Lv (Author), Jiasheng Qian (Author), Long Huang (Author), Chenjiang Qu (Author)
• Hōputu: Pukapuka
• I whakaputaina: BMC, 2024-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract Background YTHDC1, a key m(6)A nuclear reader, plays a crucial role in regulating mRNA splicing, export, and stability. However, the functional significance and regulatory mechanisms of YTHDC1 in inflammatory bowel disease (IBD) remain to be explored. Methods We established a dextran sulfat...