Biphasic Dissolution as an Exploratory Method during Early Drug Product Development

• Autori principali: Daniela Amaral Silva (Autore), Jozef Al-Gousous (Autore), Neal M. Davies (Autore), Nadia Bou Chacra (Autore), Gregory K. Webster (Autore), Elke Lipka (Autore), Gordon L. Amidon (Autore), Raimar Löbenberg (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Dissolution testing is a major tool used to assess a drug product's performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects of in vivo dissolution. Using low buffer capacit...