Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

• Main Authors: Gregory M Vercellotti (Author), Ping Zhang (Author), Julia Nguyen (Author), Fuad Abdulla (Author), Chunsheng Chen (Author), Phong Nguyen (Author), Carlos Nowotny (Author), Clifford J Steer (Author), Ann Smith (Author), John D Belcher (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesized that in SCD mice, hepatic overexpression of hemopexin would scavenge the proximal mediator of vascular activation, heme, and inhibit inflammation and microvascular stasis. To e...