1α,25(OH)2D3 Radiosensitizes Cancer Cells by Activating the NADPH/ROS Pathway

• Main Authors: Min-Tao Ji (Author), Jing Nie (Author), Xue-Fei Nie (Author), Wen-Tao Hu (Author), Hai-Long Pei (Author), Jian-Mei Wan (Author), Ai-Qing Wang (Author), Guang-Ming Zhou (Author), Zeng-Li Zhang (Author), Lei Chang (Author), Bing-Yan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The radioresistance of tumors affect the outcome of radiotherapy. Accumulating data suggest that 1α,25(OH)2D3 is a potential anti-oncogenic molecule in various cancers. In the present study, we investigated the radiosensitive effects and underlying mechanisms of 1α,25(OH)2D3in vitro and in vivo. We...