Silk Fibroin-Modified Liposome/Gene Editing System Knocks out the <i>PLK1</i> Gene to Suppress the Growth of Lung Cancer Cells

• Main Authors: Peng Pan (Author), Xueping Liu (Author), Mengqi Fang (Author), Shanlong Yang (Author), Yadong Zhang (Author), Mingzhong Li (Author), Yu Liu (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polo-like protein kinase 1 (PLK1) plays a key role in lung cancer cell mitosis. The knockout of <i>PLK1</i> gene by the CRISPR-Cas9 system can effectively inhibit the proliferation of tumor cells, but there is no suitable vector for in vivo delivery. In this study, CRISPR-Cas9 gene knock...